Cerebral blood volume

Definition: Cerebral blood volume is the total amount of blood in the brain. It is usually expressed in $\frac{ml}{100gr}$ of tissue. The total hemoglobin ( $HbT$ ) is related to cerebral blood volume by cerebral haematocrit by: $CBV\left[ \frac{10^{-3}l}{100gr} \right] = \frac{10^{-5}M}{\rho \ast H \ast R} HbT \left[ \frac{10^{-3}l}{100gr} \right]$ Where: $\rho$ is the brain density. $M$ is the molecular weight of the hemoglobin. $H$ is the large vessel hemodynamic concentration. $R$ is the cerebral to large vessels hematocrit ratio. If the hematocrit is considered to remain constant during hemodynamic response to activation, then $HbT$ is proportional to cerebral blood volume. CBV is a critical physiological indicator of tissue viability and vascular reactivity as CBV changes are directly linked to the regulation of cerebral blood flow under pathophysiological conditions

Category: Neuroscience

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Abbreviation or symbol: CBV

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https://doi.org/10.1016/j.neuroimage.2004.07.013

https://doi.org/10.1161/01.str.5.5.630

https://doi.org/10.1152/jappl.1990.68.3.1086

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