Definition: Cerebrovascular reactivity (CVR) is the ability of blood vessels to change their diameter to adjust tissue blood supply based on tissue demand. One important modulator is partial CO
pressure in the blood. CVR is a crucial regulatory component of the neurovascular coupling system, ensuring sufficient blood supply and oxygenation to the brain. It is often assessed using CO
challenges (e.g. increase in partial CO
pressure through forced CO
inspiration). CVR can be investigated by measuring the change in cerebral blood flow (CBF) or cerebral blood volume (CBV). CVR is a useful index for the assessment of vascular health in several pathologies, including stroke and neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases.
Category: Neuroscience
Related terms: Cerebral blood flow, Cerebral blood volume
Abbreviation or symbol: CVR
Synonym:
References: https://doi.org/10.3389/fphys.2021.643468/full
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English