Negative HbO2 Data
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Negative HbO2 Data

Jordan Borrell
Posts: 10
Topic starter
Active Member
Joined: 2 years ago

Hey fNIRS Community,

I'm using Homer3 to analyze my fNIRS data during a gross hand task while using a prosthetic (60 sec task) separated by rest (60 sec).  Interestingly, after using the GLM function in Homer3, I get a few channels with negative HbO2 values (i.e., classic HbO2 activation but completely negative values). I've attached a pdf of two channels with positive and negative HbO2 data as an example.  I was just curious if anyone else has seen this and if there is anything in literature that describes this.  I haven't seen this yet and hope to start a discussion on this here as I'm not sure what to make of it yet.  I appreciate any and all help with this.



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Meredith Pecukonis
Posts: 8
Active Member
Joined: 2 years ago

Hi! I've seen this but only in the infant literature. This paper may be a good starting place for you.


Issard, C., & Gervain, J. (2018). Variability of the hemodynamic response in infants: Influence of experimental design and stimulus complexity. Developmental cognitive neuroscience33, 182-193.